Expert Protein Analysis Services - Why chose PROTAGEN?
What do you want to know about your protein?
Our scientists are highly experienced providers of biopharmaceutical protein characterization services, simply because we have been developing our skills in this industry for a long time.
We have been working closely with Bruker, a leading manufacturer of contemporary mass spectrometer hardware, since their emergence on the market in the mid 1990s. This puts us in the enviable position of having had time to build our competencies to a very robust level.
Our major strengths when it comes to protein characterization are:
- An unparalleled ability to manage complex projects in the biopharmaceutical protein services industry for all aspects of protein characterization, from structure (the first step in protein identification) to function (the bioassay steps)
- The most modern mass spectrometry equipment, which we’ve invested in heavily to ensure you get the best and most sophisticated results available today
- Dedicated bioinformatics department with six full time staff with strong statistical backgrounds focused on analyzing mass spectrometer outputs.
As proteins are complex molecular entities derived from biological processes, they are almost always not fully purified and homogeneous molecules, but instead show a certain degree of structural heterogeneity. This means that the characterization of a protein always has three aspects:
- Identifying the major protein component
- Identifying the minor components
- Quantifying the minor components (both process- and product-related impurities)
Furthermore, analysis of a protein is not complete without characterizing its functional integrity.
We provide you with the full range of services, from drug discovery and development, to release testing and regulatory compliance under ICH Q6B.
You can choose from the following services.
Protein quantification by amino acid analysis and extinction coefficient. These methods allow high precision and accuracy for what is usually quite a difficult task.
Protein primary structure analysis, which involves a combination of different techniques (i.e. peptide mapping, de-novo sequencing, intact mass, N/C-terminal sequencing and disulfide linkage) to allow for a complete understanding.
Glycosylation analysis, to identify common and biologically relevant modifications. Several techniques (i.e. N-linked glycosylation, O-linked glycosylation, sialic acid, site of modification, quantification, monosaccharide) can be applied.
Bioassays, which are integral to quality assessment during the development and manufacturing of biological drugs. We can set up GMP-compliant assays for a wide range of ligand binding assays (ELISA) and cell-based assays, all of which are highly robust and reliable.
Impurities analysis, to assist with the purification of proteins and enable you to use them in research or medical applications. We can undertake testing for both process-related impurities and product-related impurities.
Your contact for Protein Characterization at Protagen AG
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Dr Katja AschermannHead of Business Development Protein Services. Phone: +49 (0) 231 9742-6300 |